An end-to-end automated solution for provisioning compounds from a large liquid library for target and hit identification efforts

Recorded On: 02/06/2018

Pfizer, like many large pharma, holds millions of compounds in its collection.  This presentation will detail the migration from a single-use tube technology requiring a fit-for-purpose building, to a standard lab footprint automated system utilizing multi-use containers and acoustic-based liquid dispensing.  The resulting solution is seamlessly integrated with a commercially available Enterprise compound-to-assay requesting tool.  Any member of the global organization has the ability to order compounds for plating to any number of assays, with plate shipment to any location. The solution, called Hit ID Provisioning System (HIPS) incorporates rule-based automation behavior in making final deliverables of assay ready plates that ensure plate quality under minimized stock consumption.  A novel compound binning algorithm compensated for the limitations of current acoustic liquid handling logistics.  Key considerations around implementation of new technology platforms will be reviewed in evaluating how the HIPS was rolled out to enable Pfizer researchers and collaborators access to the compound collection without interruption while improving plate quality and saving resources.

Keith Miller

Pfizer WR&D

Keith obtained his Bachelors in Biomedical Engineering from Cornell University and an MBA from the University of Connecticut.  He has been working in Pharma at Pfizer since 2000, and is currently located at the Groton, CT campus.  Keith heads up the Compound Management & Distribution group's hit identification lab.  His group oversees Pfizer's largest compound collection - roughly 4 million unique compounds stored in liquid format.  Keith's lab serves not only as the stewards for this collection, but also oversees the plating & distribution of compounds to support Pfizer's global portfolio of plate-based early discovery projects.  Prior to his current role, Keith has worked with a broad range of research disciplines, either directly or through his expertise with automation and liquid-handling instrumentation: High-Throughput Screening, Analytical Chemistry, Protein Crystallization, NMR Screening, Protein Cloning & Expression, and Biophysics. 

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