3-Dimensional Assays: What Must Be Done for Setting Up and Validating for Downstream Microplate Reader and Imaging Applications

Recorded On: 09/26/2017

This webinar is OPEN to both SLAS members and non-members. 

Mammalian cell culture has long been an invaluable tool in cell biology, drug discovery, and regenerative medicine. Advances in our understanding of cell physiology and failures in clinical trials have provided the impetus to move away from our standard 2-dimensional (2D) systems to a more in-vivo-like or 3-dimensional (3D) environment. The advance of new technologies and screening methodologies have allowed scientists to assess more realistic cellular functionality. Today’s webinar will focus on the cellular microenvironment and its importance when developing and screening cell-based assays using primary, stem cell, and immortalized cultures in 3D systems.

Bradley R. Larson

Principal Scientist, BioTek Instruments, Inc

Brad is a Principal Scientist at BioTek Instruments, INC., where he has worked since 2009. Prior to joining BioTek, he acquired extensive experience while employed in various capacities with multiple reagent providers. Brad’s current roles include optimizing new assay processes on BioTek’s line of automation, liquid handling, microplate detection, and imaging instrumentation. He has worked for more than 20 years with numerous automation and detection platforms, as well as a variety of cell models, to optimize 2D and 3D cell culture assays across multiple research fields. His current work has led to publications in Assay and Drug Development Technologies, The Journal of Laboratory Automation, The Journal of Biomolecular Screening, and Combinatorial Chemistry and High Throughput Screening, among others. Brad has additionally presented his work at numerous conferences across the United States, Europe, and Asia. 

Mark Rothenberg, Ph.D.

Manager Scientific Training and Education, Corning Incorporated, Life Sciences

Dr. Rothenberg graduated from Emory University with his PhD in Cell and Developmental Biology. Over the past 25 years Mark has held positions in both Academia and industry where he has developed an expertise in the areas of assay development, cell culture and cell culture scale-up.  Prior to his current position as Manager Scientific Training and Education he worked and managed the applications team.

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